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Archived Projects

1. Severe Community-Onset Staphylococcus aureus Infection Surveillance through Active Bacterial Core Surveillance Emerging Infections Program

This surveillance project engaged five Emerging Infections Program (EIP) sites (California, Georgia, Minnesota, New York, and Tennessee) that participate in the reporting of invasive MRSA through the Active Bacterial Core surveillance (ABCs). Surveillance was implemented to identify persons 0-50 years old (i.e., individuals with less chronic, underlying illness) with severe S. aureus infections requiring hospitalization, but without the previously established healthcare-associated risk factors for severe S. aureus infections such as hemodialysis, invasive device use, or concurrent or recent hospital stay (i.e., otherwise healthy). Data were collected on respiratory symptoms. Patients evaluated for inclusion in this project included those with either susceptible or methicillin-resistant S. aureus infections with isolates recovered from blood, pleural fluid, bronchoaveolar lavage (BAL), sputum, or lung tissue. Objectives for this project were to:

  • estimate the incidence, or frequency of severe community-onset S. aureus infection in otherwise healthy persons 0-50 years of age in the surveillance area
  • describe demographic, clinical, and microbiologic characteristics of persons with severe community-onset S. aureus infection
  • describe the frequency of persons with severe community-onset S. aureus infection and antecedent influenza like illness(ILI) or influenza

2. A Comparison of Clinical Outcomes from Methicillin-Resistant Staphylococcus aureus Infections due to Pulsed-Field Type USA100 versus Pulsed-Field Type USA300

This study evaluated patients who had specific invasive MRSA infections to determine if there was a difference in clinical outcomes between those infected with pulsed-field type USA100 and pulsed-field type USA300. The clinical outcomes in patients with healthcare-associated catheter-related MRSA bacteremia and in patients with community-onset MRSA pneumonia were evaluated. The projects objectives were to:

  • determine if there is a difference in clinical outcomes from healthcare-associated catheter-related MRSA bacteremia due to pulsed-field type USA100 versus pulsed-field type USA300
  • determine if there is a difference in clinical outcomes from community-onset MRSA pneumonia due to pulsed-field type USA100 versus pulsed-field type USA300